Prolistem® is a fertility support solution that can significantly enhance the chances of sperm production for men with non-obstructive azoospermia (primary testicular failure). Prolistem® is a patented and FDA-certified formula.

Our innovative six-month treatment course has yielded impressive success rates, with 48% of patients achieving successful outcomes. Among them, 23% of patients had sperm detected in their semen, while 25% of patients had successful surgical sperm extractions following the completion of Prolistem® course1.

Similar to rebooting a smartphone to fix functional issues, Prolistem® facilitates the “Spermatogenesis Restarting Process” to restore sperm production by temporarily lowering testosterone levels. Our comprehensive six-month course includes two phases. The initial phase decrease testosterone levels to create an optimal environment for sperm production, while the second phase restores normal testosterone levels and promotes healthy sperm production. 

Prolistem® offers a natural and effective solution free from harmful chemicals and synthetic ingredients. Our product results from extensive scientific research and development by a team of experts, ensuring its safety and effectiveness. Consider Prolistem® as the primary choice for azoospermia, providing a viable alternative to potentially hazardous medical interventions. Contact us today to learn more about how Prolistem® can benefit your patients.

Prolistem® utilizes glycyrrhizic acid, the active component of licorice, which undergoes in-vivo hydrolysis to glycyrrhetinic acid. This acid functions by blocking 17β-hydroxysteroid dehydrogenase (17βHSD), an enzyme responsible for converting androstenedione to testosterone. The glycyrrhizic acid used in Prolistem is derived from a specific type of licorice and undergoes a rigorous process to ensure safety. The dosage of glycyrrhizic acid in Prolistem adheres to the FDA’s recommended guidelines. The extraction process and concentration of this acid are proprietary information held by the company, as it serves as a key secret ingredient in Prolistem.

• Hormones are responsible for the maintenance of sperm production in normal conditions; however, in abnormal conditions, testosterone inhibits spermatogonial differentiation.
• Testosterone is involved in the blockage of spermatogonia stem cells in abnormal conditions such as azoospermia.
• Spermatogonia stem cells in the seminiferous tubules do not need testosterone to divide.
• Studies have shown that testosterone is critical for the late stages of spermatogenesis.
• Suppression of testosterone restores the spermatogenesis process, and in some cases, spermatogenesis was maintained after the cessation of hormonal treatment and restored fertility5.
• In many cases, short-term suppression of testosterone can restore spermatogonial stem cell division.
• Research has shown that spermatogonial stem cells can be obtained from the testicular tissue of non-obstructive azoospermic patients, which provides hope for restoring fertility.
• The cause of the block in spermatogonial differentiation is not yet clear, but it may be due to somatic damage.

Prolistem designed for Azoospermia. Many fertility supplements available on the market are specifically formulated to support sperm health, particularly targeting men with oligospermia (low sperm count). These supplements aim to improve sperm count, motility, and overall sperm quality. However, it’s important to note that these supplements are generally not designed or marketed as a treatment for azoospermia, which is a condition characterized by the absence of sperm in semen.

Azoospermia requires a different approach, as it typically indicates an issue with sperm production or delivery. In cases of azoospermia, it’s crucial for individuals to consult with a healthcare professional, such as a fertility specialist or urologist, who can provide appropriate guidance and suggest potential treatment options based on the specific underlying cause.

It’s essential to choose fertility supplements or treatments based on individual needs and under the guidance of healthcare professionals to ensure the best possible outcomes.

In 2012, the Department of Urology at Presbyterian Hospital (New York) published an article about the hormone treatments before a TESE:
“Men with non-obstructive azoospermia and hypogonadism often respond to hormonal therapy with an increase in testosterone levels, but neither baseline testosterone level nor response to hormonal therapy appears to affect overall sperm retrieval, clinical pregnancy or live birth rates.”

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No, your testosterone levels will stay in the normal range, as natural herbs cannot completely reduce the testosterone levels.

The U.S. Food and Drug Administration (FDA) does not approve supplements in the same way it approves prescription drugs. Dietary supplements are regulated under a different set of rules than drugs. The FDA is responsible for overseeing the safety and labeling of dietary supplements, but they do not conduct the same rigorous pre-market testing and approval process as they do for drugs.

Under the Dietary Supplement Health and Education Act (DSHEA) of 1994, supplement manufacturers are responsible for ensuring the safety of their products and making sure their claims are not false or misleading. However, the FDA has the authority to take action against any supplement that is found to be unsafe or contains misleading claims.

Supplement manufacturers are not required to obtain FDA approval before marketing their products. However, they must notify the FDA about the ingredients in their products, and they are expected to manufacture them in compliance with good manufacturing practices (GMPs).

It’s important for consumers to be cautious when using dietary supplements and to do their own research. While the FDA does regulate supplements to some extent, it’s advisable to consult with healthcare professionals and make informed decisions about supplement usage based on individual needs and circumstances.

Prolistem is manufactured in a facility that follows good manufacturing practices (GMP), ensuring quality and safety standards are met. Additionally, Prolistem has obtained a certificate of free sale from the FDA, indicating that it meets the necessary requirements to be legally marketed and sold.

Prolistem® is generally considered safe, and it aims to minimize side effects. However, like any dietary supplement or medication, individual reactions may vary. It is important to note that certain individuals with specific health conditions may be more sensitive to the effects of Prolistem®. Such conditions may include heart failure, heart disease, fluid retention, high blood pressure (hypertension), diabetes, kidney disease, the use of antidepressant medications, and liver disease.

If an individual has any of these conditions or is taking medications for them, it is advisable to consult with a healthcare professional before starting Prolistem® or any other supplement. A healthcare professional can evaluate the individual’s specific situation, consider potential interactions or sensitivities, and provide personalized recommendations.

Overall, it is crucial to prioritize safety and seek guidance from healthcare professionals to ensure the most appropriate and beneficial approach to individual health concerns.

Try not to miss taking Stage I and II treatments. Although missing a day or two in Stage III will not affect the overall results, missing many days could affect the results. If you miss a day or two, do not double up or take more than the suggested dosage.

No. Keep it in a cool, dry, and dark place.

For men diagnosed with primary testicular failure, the use of surgical sperm retrieval methods is often necessary to obtain viable sperm for in vitro fertilization (IVF). We strongly recommend undergoing a six-month course of Prolistem® treatment for two important reasons:

Firstly, our treatment has the potential to enhance sperm count in the semen, potentially eliminating the need for a biopsy procedure. By improving sperm production, Prolistem® may increase the likelihood of finding viable sperm in the ejaculate.

Secondly, even if the semen analysis reveals an absence of sperm, Prolistem® treatment can significantly improve the success rates of testicular sperm extraction. This means that individuals who previously had no viable sperm in their semen may have a better chance of obtaining sperm through surgical retrieval methods.

Considering these factors, it is advisable for individuals to seriously consider testicular sperm extraction following the completion of Prolistem® treatment. This combined approach maximizes the chances of obtaining viable sperm for use in assisted reproductive techniques like IVF.

Yes, the capsules are Hala- and Kosher-certified medications by Capsuline.