SCIENTIFIC SOULTION FOR AZOOSPERMIA
At Prolistem, we are committed to helping men with azoospermia (zero sperm count) using the latest scientific discoveries. Our patented, FDA-certified formula is designed to support the body in naturally restarting sperm production. Based on advanced research, Prolistem offers a new hope for men facing fertility challenges. Trust Prolistem to be your partner on the journey to fatherhood, where science brings real solutions.


Prolistem is a novel approach and treatment strategy designed specifically for men with primary testicular failure.
Current guidelines recommend procedures like Micro-TESE a costly, emotionally draining process with limited success rates. But what if there was another way?
The Journey to Prolistem
Prolistem didn’t happen overnight. It’s the result of years of groundbreaking discoveries…
One discovery led to another… each piece of research bringing us closer to a solution.
The connection between our findings and the work of other researchers paved the way… and it all led to Prolistem treatment.
What is Prolistem?
Prolistem is a natural, science-backed treatment designed to reactivate spermatogonial stem cells and restore sperm production in men with non-obstructive azoospermia.
During the six-month treatment, the first three months focus on the Spermatogenesis Restarting Process—temporarily lowering testosterone levels to create the ideal environment for sperm development.
In the final three months, testosterone levels return to normal, supporting healthy sperm production.
How Does Prolistem Work?
Prolistem works by temporarily reducing testosterone levels, allowing the crucial early stages of spermatogenesis to take place. This is achieved through unique components like glycyrrhizic acid, omega-3 fatty acids, and lignans.
Glycyrrhizic acid, for example, blocks 17β-hydroxysteroid dehydrogenase, which catalyzes the conversion of androstenedione to testosterone.
Prolistem Mechanism
Sperm production relies on the support of Sertoli cells through two pathways: the Classic Pathway and the Non-Classic Pathway.
Think of the Classic Pathway as the ‘main road’ for sperm production—it requires high testosterone levels to function.
But when testosterone drops, the Non-Classic Pathway acts as a ‘backup road,’ ensuring the process continues.
Prolistem works by activating this backup mechanism, helping to improve sperm production in men with azoospermia.
Clinical Results
Different clinical studies have shown promising results: about 23% of patients using Prolistem found sperm in their semen. Additionally, the success rate of micro-TESE increased from 22% to 54% when combined with Prolistem.
The Goal of Prolistem
The goal of Prolistem is to maximize sperm retrieval while minimizing unnecessary surgeries—offering patients a new path to hope.
What to Know Before Starting Prolistem
- Do not take Prolistem alongside any other fertility supplements or treatments.
- Do not expect natural pregnancy, as this rarely happens.
- Outcomes cannot be guaranteed due to the complexity of azoospermia.
- Perform monthly sperm tests during the treatment to monitor progress.
- If no sperm is found after completing the full course, perform micro-TESE within one-two months.
Visit our offical website prolistem.com to order and explore how Prolistem can help you on your journey.